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Scientific Publications

Dirk M. Nettelbeck, Ronald D. Alvarez and David T. Curiel, (July 2008) Tumor-Busting Viruses.  Scientific American, Special Editions, New Answers for Cancer. p.72

Hedley, S.J., Chen, J., Mountz, J.D., Li, J., Curiel, D.T., Korokhov, N., and Kovesdi, I. (2006). Targeted and shielded adenovectors for cancer therapy. Cancer Immunol Immunother, 55(11), 1412-1419.

Hedley, S.J., Auf der Maur, A., Hohn, S., Escher, D., Barberis, A., Glasgow, J.N., Douglas, J.T., Korokhov, N., and Curiel, D.T. (2006). An adenovirus vector with a chimeric fiber incorporating stabilized single chain antibody achieves targeted gene delivery. Gene Ther, 13(1), 88-94.

Noureddini, S.C., Krendelshchikov, A., Simonenko, V., Hedley, S.J., Douglas, J.T., Curiel, D.T., and Korokhov, N. (2006). Generation and selection of targeted adenoviruses embodying optimized vector properties. Virus Res, 116(1-2), 185-195.

Breidenbach, M., Rein, D.T., Everts, M., Glasgow, J.N., Wang, M., Passineau, M.J., Alvarez, R.D., Korokhov, N., and Curiel, D.T. (2005). Mesothelin-mediated targeting of adenoviral vectors for ovarian cancer gene therapy. Gene Ther, 12(2), 187-193.

Everts, M., Kim-Park, S.A., Preuss, M.A., Passineau, M.J., Glasgow, J.N., Pereboev, A.V., Mahasreshti, P.J., Grizzle, W.E., Reynolds, P.N., and Curiel, D.T. (2005). Selective induction of tumor-associated antigens in murine pulmonary vasculature using double-targeted adenoviral vectors. Gene Ther, 12(13), 1042-1048.

Hosokawa, M., Kadota, R., Shichijo, S., Itoh, K., Dmitriev, I., Krasnykh, V., Curiel, D.T., Takue, Y., Wakasugi, H., Takashima, S., and Heike, Y. (2005). Cell cycle arrest and apoptosis induced by SART-1 gene transduction. Anticancer Res, 25(3B), 1983-1990.

Korokhov, N., de Gruijl, T.D., Aldrich, W.A., Triozzi, P.L., Banerjee, P.T., Gillies, S.D., Curiel, T.J., Douglas, J.T., Scheper, R.J., and Curiel, D.T. (2005). High efficiency transduction of dendritic cells by adenoviral vectors targeted to DC-SIGN. Cancer Biol Ther, 4(3), 289-294.

Korokhov, N., Noureddini, S.C., Curiel, D.T., Santegoets, S.J., Scheper, R.J., and de Gruijl, T.D. (2005). A single-component CD40-targeted adenovirus vector displays highly efficient transduction and activation of dendritic cells in a human skin substrate system. Mol Pharm, 2(3), 218-223.

Noureddini, S.C., and Curiel, D.T. (2005). Genetic targeting strategies for adenovirus. Mol Pharm, 2(5), 341-347.

Ono, H.A., Davydova, J.G., Adachi, Y., Takayama, K., Barker, S.D., Reynolds, P.N., Krasnykh, V.N., Kunisaki, C., Shimada, H., Curiel, D.T., and Yamamoto, M. (2005). Promoter-controlled infectivity-enhanced conditionally replicative adenoviral vectors for the treatment of gastric cancer. J Gastroenterol, 40(1), 31-42.

Tsuruta, Y., Pereboeva, L., Glasgow, J.N., Luongo, C.L., Komarova, S., Kawakami, Y., and Curiel, D.T. (2005). Reovirus sigma1 fiber incorporated into adenovirus serotype 5 enhances infectivity via a CAR-independent pathway. Biochem Biophys Res Commun, 335(1), 205-214.

Wang, M., Hemminki, A., Siegal, G.P., Barnes, M.N., Dmitriev, I., Krasnykh, V., Liu, B., Curiel, D.T., and Alvarez, R.D. (2005). Adenoviruses with an RGD-4C modification of the fiber knob elicit a neutralizing antibody response but continue to allow enhanced gene delivery. Gynecol Oncol, 96(2), 341-348.

Glasgow, J.N., Bauerschmitz, G.J., Curiel, D.T., and Hemminki, A. (2004). Transductional and transcriptional targeting of adenovirus for clinical applications. Curr Gene Ther, 4(1), 1-14.

Grandi, P., Wang, S., Schuback, D., Krasnykh, V., Spear, M., Curiel, D.T., Manservigi, R., and Breakefield, X.O. (2004). HSV-1 virions engineered for specific binding to cell surface receptors. Mol Ther, 9(3), 419-427.

Rivera, A.A., Wang, M., Suzuki, K., Uil, T.G., Krasnykh, V., Curiel, D.T., and Nettelbeck, D.M. (2004). Mode of transgene expression after fusion to early or late viral genes of a conditionally replicating adenovirus via an optimized internal ribosome entry site in vitro and in vivo. Virology, 320(1), 121-134.

Timares, L., Douglas, J.T., Tillman, B.W., Krasnykh, V., and Curiel, D.T. (2004). Adenovirus-mediated gene delivery to dendritic cells. Methods Mol Biol, 246, 139-154.

Belousova, N., Korokhov, N., Krendelshchikova, V., Simonenko, V., Mikheeva, G., Triozzi, P.L., Aldrich, W.A., Banerjee, P.T., Gillies, S.D., Curiel, D.T., and Krasnykh, V. (2003). Genetically targeted adenovirus vector directed to CD40-expressing cells. J Virol, 77(21), 11367-11377.

Korokhov, N., Mikheeva, G., Krendelshchikov, A., Belousova, N., Simonenko, V., Krendelshchikova, V., Pereboev, A., Kotov, A., Kotova, O., Triozzi, P.L., Aldrich, W.A., Douglas, J.T., Lo, K.M., Banerjee, P.T., Gillies, S.D., Curiel, D.T., and Krasnykh, V. (2003). Targeting of adenovirus via genetic modification of the viral capsid combined with a protein bridge. J Virol, 77(24), 12931-12940.

Pereboeva, L., Komarova, S., Mikheeva, G., Krasnykh, V., and Curiel, D.T. (2003). Approaches to utilize mesenchymal progenitor cells as cellular vehicles. Stem Cells, 21(4), 389-404.

Takayama, K., Reynolds, P.N., Short, J.J., Kawakami, Y., Adachi, Y., Glasgow, J.N., Rots, M.G., Krasnykh, V., Douglas, J.T., and Curiel, D.T. (2003). A mosaic adenovirus possessing serotype Ad5 and serotype Ad3 knobs exhibits expanded tropism. Virology, 309(2), 282-293.

Yamamoto, M., Davydova, J., Wang, M., Siegal, G.P., Krasnykh, V., Vickers, S.M., and Curiel, D.T. (2003). Infectivity enhanced, cyclooxygenase-2 promoter-based conditionally replicative adenovirus for pancreatic cancer. Gastroenterology, 125(4), 1203-1218.

Belousova, N., Krendelchtchikova, V., Curiel, D.T., and Krasnykh, V. (2002). Modulation of adenovirus vector tropism via incorporation of polypeptide ligands into the fiber protein. J Virol, 76(17), 8621-8631.

Haviv, Y.S., Blackwell, J.L., Kanerva, A., Nagi, P., Krasnykh, V., Dmitriev, I., Wang, M., Naito, S., Lei, X., Hemminki, A., Carey, D., and Curiel, D.T. (2002). Adenoviral gene therapy for renal cancer requires retargeting to alternative cellular receptors. Cancer Res, 62(15), 4273-4281.

Haviv, Y.S., Takayama, K., Glasgow, J.N., Blackwell, J.L., Wang, M., Lei, X., and Curiel, D.T. (2002). A model system for the design of armed replicating adenoviruses using p53 as a candidate transgene. Mol Cancer Ther, 1(5), 321-328.

Sullivan, D.E., Mondelli, M.U., Curiel, D.T., Krasnykh, V., Mikheeva, G., Gaglio, P., Morris, C.B., Dash, S., and Gerber, M.A. (2002). Construction and characterization of an intracellular single-chain human antibody to hepatitis C virus non-structural 3 protein. J Hepatol, 37(5), 660-668.

Asada-Mikami, R., Heike, Y., Kanai, S., Azuma, M., Shirakawa, K., Takaue, Y., Krasnykh, V., Curiel, D.T., Terada, M., Abe, T., and Wakasugi, H. (2001). Efficient gene transduction by RGD-fiber modified recombinant adenovirus into dendritic cells. Jpn J Cancer Res, 92(3), 321-327.

Cripe, T.P., Dunphy, E.J., Holub, A.D., Saini, A., Vasi, N.H., Mahller, Y.Y., Collins, M.H., Snyder, J.D., Krasnykh, V., Curiel, D.T., Wickham, T.J., DeGregori, J., Bergelson, J.M., and Currier, M.A. (2001). Fiber knob modifications overcome low, heterogeneous expression of the coxsackievirus-adenovirus receptor that limits adenovirus gene transfer and oncolysis for human rhabdomyosarcoma cells. Cancer Res, 61(7), 2953-2960.

Krasnykh, V., Belousova, N., Korokhov, N., Mikheeva, G., and Curiel, D.T. (2001). Genetic targeting of an adenovirus vector via replacement of the fiber protein with the phage T4 fibritin. J Virol, 75(9), 4176-4183.

Suzuki, K., Fueyo, J., Krasnykh, V., Reynolds, P.N., Curiel, D.T., and Alemany, R. (2001). A conditionally replicative adenovirus with enhanced infectivity shows improved oncolytic potency. Clin Cancer Res, 7(1), 120-126.